B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex

GARP Complex on T Regulatory β TGF - 1 from the Latent β Release of Active TGF

GARP Complex on T Regulatory β TGF - 1 from the Latent β

Mediated by Integrin 1 / GARP Complex on T Regulatory β TGF - 1 from the Latent β Release of Active TGF

Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer

GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly expressed on regulatory T lymphocytes and platelets. GARP regulates the availability of membrane-bound latent TGF-β and modulates its activation. For this reason, GARP expression on immune and non-immune cells is involved in mai...

Integrin 1 / GARP Complex on T Regulatory β TGF - 1 from the Latent β Release of Active TGF -